(R)-(-)-3-Chloro-1,2-propanediol Chemical Properties

Melting point:

-40°C

Boiling point:

213 °C(lit.)

alpha 

-0.9 º (neat)

Density 

1.321 g/mL at 20 °C(lit.)

vapor pressure 

0.04 mm Hg ( 25 °C)

refractive index 

n20/D 1.48(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Chloroform, Methanol

form 

clear liquid

pka

13.28±0.20(Predicted)

Specific Gravity

1.322

color 

Colorless to Brown

optical activity

[α]20/D 1°, neat

Water Solubility 

soluble

BRN 

2202928

InChIKey

SSZWWUDQMAHNAQ-VKHMYHEASA-N

LogP

0.5 at 25℃

CAS DataBase Reference

57090-45-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25-41-68-62-36/37/38-23/25-21

Safety Statements 

26-28-39-45-36/37/39

RIDADR 

UN 2689 6.1/PG 3

WGK Germany 

3

RTECS 

TY4025000

F 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29053200

MSDS

• Language:English Provider:(R)-(-)-3-Glycerol alpha-monochlorohydrin
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(R)-(-)-3-Chloro-1,2-propanediol Usage And Synthesis

Chemical Properties

clear light yellow liquid

Uses

(R)-(-)-3-Chloro-1,2-propanediol is used as a reagent in the synthesis of PA-824, which is a promising antituberculosis drug candidate that has been synthesized. It is also used in the manufacture of L-carnitine, which is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria.

Definition

ChEBI: The (R)-stereoisomer of 3-chloro-1,2-propanediol.

Health Hazard

The toxicological evaluation revealed that (R)-(-)-3-Chloro-1,2-propanediol was genotoxic in humans and had anti-fertility effects in male rats. The discharge of this compound into wastewater might cause serious environmental hazards[1].

References

[1] Yun‐Xu Yang. “Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine.” Journal of Chemical Research-s 93 1 (2011): 371–372.

(R)-(-)-3-Chloro-1,2-propanediol(57090-45-6)Related Product Information

• 1-Methoxy-2-propanol
• Propylene glycol
• 1,3-Propanediol
• 2-METHYL-1,3-PROPANEDIOL
• Glycerol
• 1-Methoxy-2-propyl acetate
• 1-Phenoxy-2-propanol
• (R)-(-)-1,2-Propanediol
• DI(PROPYLENE GLYCOL) BUTYL ETHER
• Nitroglycerin
• (R)-3-CHLORO-1,2-PROPANEDIOL ACETONIDE,(R)-3-CHLORO-1,2-PROPANEDIOL ACETONIDE
• 3-CHLORO-1,2-PROPANE-D5-DIOL
• 3-Chloro-1,2-propanediol
• Difluorochloromethane
• 3-Chloro-1,2-propanediol dinitrate,3-Chloro-1,2-propanediol dinitrate
• (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
• 3-Chloro-1,2-propanediol 1-acetate,3-Chloro-1,2-propanediol 1-acetate
• (S)-(+)-3-Chloro-1,2-propanediol