(R)-(-)-3-Chloro-1,2-propanediol
- Product Name
- (R)-(-)-3-Chloro-1,2-propanediol
- CAS No.
- 57090-45-6
- Chemical Name
- (R)-(-)-3-Chloro-1,2-propanediol
- Synonyms
- (R)-3-CHLOROPROPANE-1,2-DIOL;(R)-3-CHLORO-1,2-PROPANEDIOL;2-propanediol;(R)-3-ChL;(R)-3-MCPD;(R)-(-)-3-Chloro-1;R-Chloropropanediol;oro-1,2-propanedioL;(R)-(-)-3-Chloro-1,2;Chloropropanediol,98%
- CBNumber
- CB8194510
- Molecular Formula
- C3H7ClO2
- Formula Weight
- 110.54
- MOL File
- 57090-45-6.mol
(R)-(-)-3-Chloro-1,2-propanediol Property
- Melting point:
- -40°C
- Boiling point:
- 213 °C(lit.)
- alpha
- -0.9 º (neat)
- Density
- 1.321 g/mL at 20 °C(lit.)
- vapor pressure
- 0.04 mm Hg ( 25 °C)
- refractive index
- n20/D 1.48(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- soluble in Chloroform, Methanol
- form
- clear liquid
- pka
- 13.28±0.20(Predicted)
- Specific Gravity
- 1.322
- color
- Colorless to Brown
- optical activity
- [α]20/D 1°, neat
- Water Solubility
- soluble
- BRN
- 2202928
- InChI
- 1S/C3H7ClO2/c4-1-3(6)2-5/h3,5-6H,1-2H2/t3-/m0/s1
- InChIKey
- SSZWWUDQMAHNAQ-VKHMYHEASA-N
- SMILES
- OC[C@@H](O)CCl
- LogP
- 0.5 at 25℃
- CAS DataBase Reference
- 57090-45-6(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-41-68-62-36/37/38-23/25-21
- Safety Statements
- 26-28-39-45-36/37/39
- RIDADR
- UN 2689 6.1/PG 3
- WGK Germany
- 3
- RTECS
- TY4025000
- F
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29053200
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials - Hazard Classifications
- Acute Tox. 2 Inhalation
Acute Tox. 3 Oral
Carc. 2
Eye Dam. 1
Met. Corr. 1
Repr. 1B
Skin Irrit. 2
STOT RE 1 Oral
STOT SE 1 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H330Fatal if inhaled
H351Suspected of causing cancer
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P234Keep only in original container.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 540056
- Product name
- (R)-(?)-3-Chloro-1,2-propanediol
- Purity
- 97%, optical purity ee: 98% (GLC)
- Packaging
- 5g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- M0967
- Product name
- (R)-(-)-3-Chloro-1,2-propanediol
- Purity
- >96.0%(GC)
- Packaging
- 10g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- M0967
- Product name
- (R)-(-)-3-Chloro-1,2-propanediol
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $131
- Updated
- 2025/07/31
- Product number
- C380465
- Product name
- (R)-(-)-3-Chloro-1,2-propanediol
- Packaging
- 25g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 075856
- Product name
- (R)-3-Chloro-1,2-propanediol
- Purity
- 95+%
- Packaging
- 100g
- Price
- $110
- Updated
- 2021/12/16
(R)-(-)-3-Chloro-1,2-propanediol Chemical Properties,Usage,Production
Chemical Properties
clear light yellow liquid
Uses
(R)-(-)-3-Chloro-1,2-propanediol is used as a reagent in the synthesis of PA-824, which is a promising antituberculosis drug candidate that has been synthesized. It is also used in the manufacture of L-carnitine, which is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria.
Definition
ChEBI: The (R)-stereoisomer of 3-chloro-1,2-propanediol.
Health Hazard
The toxicological evaluation revealed that (R)-(-)-3-Chloro-1,2-propanediol was genotoxic in humans and had anti-fertility effects in male rats. The discharge of this compound into wastewater might cause serious environmental hazards[1].
Synthesis
Method 1 (CN202111237118.2):
After mixing and reacting (R)epichlorohydrin, (RR)Salen cobalt(III) catalyst completely, diluting with water, filtering, separating out the precipitate of (RR)Salen cobalt(III) catalyst, and then distilling the water under reduced pressure, and then distilling under reduced pressure to obtain (R)-3-chloro-1,2-propanediol. The (R)-3-chloro-1,2-propanediol prepared by this method has a chemical purity of >99.5% and a chiral purity (EE) of >99.8%, and has the advantages of simple synthesis, low cost, and easy to be applied industrially.
Method 2 (CN201510206172.9):
1) In the presence of an acidic catalyst, (S)-3-chloro-1,2-epoxypropane and water were subjected to a ring-opening reaction to obtain a ring-opening mixture;
2) The base was subjected to a neutralization reaction with the ring-opening mixture to obtain the neutralized mixture;
3) The alkali was neutralized with the ring-opening mixture to obtain the ring-opening mixture;
4) The base was subjected to the ring-opening reaction with the ring-opening mixture;
5) The alkali was subjected to the ring-opening mixture. p>
3) Removing water from the neutralization mixture and filtering to obtain the filtrate;
4) Fractionating the filtrate at 30-35 pa and 125-128C to produce (R)-3-chloro-1,2-propanediol.
This method has excellent yields, and the (R)-3-chloro-1,2-propanediol has excellent total purity and low water content, especially the chiral purity can be as high as 99.5%.
References
[1] Yun‐Xu Yang. “Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine.” Journal of Chemical Research-s 93 1 (2011): 371–372.
(R)-(-)-3-Chloro-1,2-propanediol Preparation Products And Raw materials
Raw materials
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View Lastest Price from (R)-(-)-3-Chloro-1,2-propanediol manufacturers
- Product
- (R)-(-)-3-Chloro-1,2-propanediol 57090-45-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-26
- Product
- (R)-3-Chloro-1,2-propanediol 57090-45-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-07-30
- Product
- (R)-3-Chloro-1,2-propanediol 57090-45-6
- Price
- US $9.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-23