TYRPHOSTIN B44
TYRPHOSTIN B44 Basic information
- Product Name:
- TYRPHOSTIN B44
- Synonyms:
-
- (R)-(E)-2-CYANO-3-(3',4'-DIHYDROXYPHENYL)-N-(1-PHENYLETHYL)-2-PROPENAMIDE
- (-)-(R)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE
- (-)-(R)-N-(ALPHA-METHYLBENZYL)-3,4-DIHYDROXYBENZYLIDINECYANOACETAMIDE
- TYRPHOSTIN AG 527
- TYRPHOSTIN B44
- TYRPHOSTIN B44(-)
- TRYPHOSTIN AG 527
- (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-2-propenamide
- CAS:
- 133550-32-0
- MF:
- C18H16N2O3
- MW:
- 308.33
- Product Categories:
-
- Intracellular Signaling
- Protein Kinase
- Mol File:
- 133550-32-0.mol
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TYRPHOSTIN B44 Chemical Properties
- Boiling point:
- 603.0±55.0 °C(Predicted)
- Density
- 1.299±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO or ethanol: soluble
- form
- Yellow solid.
- pka
- 8.81±0.10(Predicted)
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
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TYRPHOSTIN B44 Usage And Synthesis
Uses
Tyrphostin B44, (-) enantiomer is a potent inhibitor of (EGFR) kinase.
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.4 μ M), more active than the (+) enantiomer ((S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide ). Selective over ErbB2.
TYRPHOSTIN B44Supplier
J & K SCIENTIFIC LTD.
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