Basic information Safety Supplier Related

N-Arachidonyl maleimide

Basic information Safety Supplier Related

N-Arachidonyl maleimide Basic information

Product Name:
N-Arachidonyl maleimide
Synonyms:
  • N-Arachidonyl maleimide
  • 1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione
  • 1-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenyl]pyrrole-2,5-dione
  • 1H-Pyrrole-2,5-dione, 1-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-
  • N-Arachidonylmaleimide >=98% (HPLC)
CAS:
876305-42-9
MF:
C24H35NO2
MW:
369.54
Product Categories:
  • Cannabinoid receptor
Mol File:
876305-42-9.mol
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N-Arachidonyl maleimide Chemical Properties

Boiling point:
492.9±34.0 °C(Predicted)
Density 
0.984±0.06 g/cm3(Predicted)
storage temp. 
Store at -80°C
solubility 
≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
solid
pka
-2.21±0.20(Predicted)
color 
Colorless to light yellow
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Safety Information

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
WGK Germany 
1
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N-Arachidonyl maleimide Usage And Synthesis

Biological Activity

n-arachidonyl maleimide is a monoacylglycerol lipase (mgl) or mgl-like activity inhibitor.2-arachidonoyl glycerol (2-ag), an endogenous agonist of the central cannabinoid and peripheral cannabinoid receptors, is present with high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found brain. monoacylglycerol lipase has been identified to hydrolyze 2-ag to arachidonic acid and glycerol, thereby terminating its biological actions.

in vitro

previous study found that n-arachidonyl maleimide could increase the endogenous levels of 2-ag. moreover, in agonist-stimulated guanosine 5'-o-(3-[(35)s]thio)triphosphate binding assay, n-arachidonyl maleimide was able to raise the potency of 2-ag, but not anandamide (aea). in addition, unmasking of 2-ag effects of n-arachidonyl maleimide that were only partially reversed by sr141716a gave further support for the existence of non-cb(1), non-cb(2) cannabinoid receptors [1].

in vivo

animal study showed that n-arachidonyl maleimide could unmask 2-ag activity in a tetrad of in vivo tests sensitive to the effects of cannabinoids in mice. the efficacy of 2-ag to produce hypothermia was reduced by the treatment of n-arachidonyl maleimide compared with delta(9)-tetrahydrocannabinol. all tetrad effects were partially cb(1) receptor-mediated because they could be attenuated by cb(1) antagonist sr141716a and in cb(1)(-/-) mice [1].

IC 50

140 nm

References

[1] burston jj et al. n-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. j pharmacol exp ther. 2008 nov;327(2):546-53.

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