URB602
URB602 Basic information
- Product Name:
- URB602
- Synonyms:
-
- URB602
- Biphenyl-3-yl Carbamic Acid, Cyclohexyl Ester
- cyclohexyl biphenyl-3-ylcarbaMate
- [1,1’-Biphenyl]-3-yl-carbamic acid cyclohexyl ester
- Monoacylglycerol Lipase Inhibitor, URB602
- N-[1,1'-Biphenyl]-3-yl-
- URB 602;URB-602
- N-[1,1'-Biphenyl]-3-yl-carbamic acid cyclohexyl ester
- CAS:
- 565460-15-3
- MF:
- C19H21NO2
- MW:
- 295.38
- Product Categories:
-
- Chemical for Research
- Research Chemical
- All Inhibitors
- Inhibitors
- Pharmaceutical intermediate
- Aromatics
- Mol File:
- 565460-15-3.mol
URB602 Chemical Properties
- Melting point:
- 122-123°C
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- color
- white to off-white
URB602 Usage And Synthesis
Chemical Properties
Off-White Solid
Uses
URB602 is a selective inhibitor of MGL, exhibiting an IC50 of 28 for the rat brain enzyme. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 , or other lipid metabolizing enzymes such as diacylglycerol lipase or
Uses
URB602 is a selective inhibitor of MGL, exhibiting an IC50 of 28 μM for the rat brain enzyme. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 μM, or other lipid metabolizing enzymes such as diacylglycerol lipase or cyclooxygenase-2.5 6 Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
in vivo
URB602 at doses of 20 and 40 mg/kg tends to reduce upper GI transit and slow colonic propulsion. When taken together as whole gut transit, URB602 dose dependently inhibits transit (P<0.05) compared with the vehicle control group. The inhibitory action of 40 mg/kg URB602 on whole gut transit is absent in these mice, indicating CB1 receptor involvement in the inhibitory action[3]. URB602 decreases the AUC of pain behaviour during the early phase of the formalin test with an ED50 of 0.06±0.028 μg for JZL184 and 120±51.3 μg for URB602 in adult male Sprague-Dawley rats. Both MGL inhibitors also suppresses pain behaviour during the late phase of formalin pain, with an ED50 of 0.03±0.011 μg for JZL184 and 66±23.9 μg for URB602[4].
URB602Supplier
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