Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Chemical Properties

storage temp. 

-15°C

solubility 

Ethyl Acetate: 10 mg/ml

form 

A crystalline solid

color 

White to off-white

Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Usage And Synthesis

Uses

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].

Biological Activity

Cell permeable: yes', 'Primary Target
Cathepsin L', 'Product does not compete with ATP.', 'Reversible: no

IC 50

cathepsin L

References

[1] Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. DOI:10.1074/jbc.M201107200
[2] Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872. DOI:10.1126/scitranslmed.abf7872