Basic information Safety Supplier Related

PLATELET ACTIVATING FACTOR-16, ANTAGONIST

Basic information Safety Supplier Related

PLATELET ACTIVATING FACTOR-16, ANTAGONIST Basic information

Product Name:
PLATELET ACTIVATING FACTOR-16, ANTAGONIST
Synonyms:
  • PLATELET ACTIVATING FACTOR-16, ANTAGONIST
  • 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)-HEXANOLAMINE
  • 1-O-HEXADECYL-2-ACETYL-SN-GLYCEROL-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE
  • 1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYL(N,N,N-TRIMETHYL) HEXANOLAMINE
  • 1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE
  • L-ALPHA-PHOSPHATIDYL(N,N,N-TRIMETHYL)HEXANOLAMINE, BETA-ACETYL, GAMMA-HEXADECYL
  • HEXANOLAMINO PAF C-16
  • 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphono(N,N,N-trimethyl)hexanolamine
CAS:
137566-83-7
MF:
C30H62NO7P
MW:
579.79
Mol File:
137566-83-7.mol
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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Chemical Properties

storage temp. 
−20°C
solubility 
≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
form 
lyophilized powder
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Safety Information

WGK Germany 
3

MSDS

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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Usage And Synthesis

Uses

1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine is a PAF antagonist.

Definition

ChEBI: 1-o-hexadecyl-2-o-acetyl-sn-glyceryl-3-phosphoryl(n,n,n-trimethyl)hexanolamine is a glycerophospholipid.

Biological Activity

hexanolamino paf c-16 is a paf analog with paf agonist/antagonist properties.platelet activating factor (paf; c16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. paf also stimulates the production of active oxygen species by human monocyte - derived macrophages [1].hexanolamino paf c-16, a paf analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. in human monocyte-derived macrophages, hexanolamino paf c-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (h202) in response to paf [1]. in both rabbit platelets and guinea-pig macrophages, hexanolamino paf c-16 acted as a partial agonist [2].

References

[1]. rouis m, nigon f, chapman mj. platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. biochem biophys res commun. 1988 nov 15;156(3):1293-301.
[2]. stewart ag, grigoriadis g. structure-activity relationships for platelet-activating factor (paf) and analogues reveal differences between paf receptors on platelets and macrophages. j lipid mediat. 1991 nov;4(3):299-308.

PLATELET ACTIVATING FACTOR-16, ANTAGONISTSupplier

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