5,6-DiHETE Chemical Properties

Boiling point:

515.8±50.0 °C(Predicted)

Density 

1.040±0.06 g/cm3(Predicted)

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml

pka

4.68±0.10(Predicted)

form 

Oil

color 

Light yellow to yellow

5,6-DiHETE Usage And Synthesis

Description

Eicosapentaenoic acid (EPA; ) is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. EPA is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA following epoxidation of the α-5 double bond. The biological activity of (±)5(6)-DiHETE has not been documented.

Uses

5,6-DiHETE is an anti-inflammatory lipid mediator derived from eicosapentaenoic acid (EPA). 5,6-DiHETE has the ability to suppress vascular hyperpermeability during inflammation and is used in the research of inflammatory diseases[1].

Definition

ChEBI: 5,6-DiHETE is a polyunsaturated fatty acid and a hydroxy fatty acid.

References

[1] Misato Kida, et al. A novel eicosapentaenoic acid-derived anti-inflammatory lipid mediator 5,6-DiHETE is abundant in blue back fish intestines. J Food Sci. 2020, 85, 7. DOI:10.1111/1750-3841.15179
[2] Kida M, et al. A novel eicosapentaenoic acid-derived anti-inflammatory lipid mediator 5,6-DiHETE is abundant in blue back fish intestines. J Food Sci. 2020 Jul;85(7):1983-1987. DOI:10.1111/1750-3841.15179