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LHW090-A7

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LHW090-A7 Basic information

Product Name:
LHW090-A7
Synonyms:
  • LHW090-A7
  • (alphaS)-3'-Chloro-alpha-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino][1,1'-biphenyl]-4-propanoic acid
  • EOS-61103
  • (S)-3-(3'-Chloro-[1,1'-biphenyl]-4-yl)-2-(((S)-1-ethoxy-1-oxopropan-2-yl)amino)propanoic acid
  • Sodium (2S)-3-(3'-chloro-[1,1'-biphenyl]-4-yl)-2-{[(2S)-1-ethoxy-1-oxopropan-2-yl]amino}propanoate
  • CS-2208
  • [1,1'-Biphenyl]-4-propanoic acid, 3'-chloro-α-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino]-, (αS)-
  • (αS)-3'-Chloro-α-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino][1,1'-biphenyl]-4-propanoic acid
CAS:
1308256-94-1
MF:
C20H22ClNO4
MW:
375.85
Mol File:
1308256-94-1.mol
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LHW090-A7 Chemical Properties

solubility 
DMSO: 5 mg/ml
Ethanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
InChI
InChI=1/C20H22ClNO4/c1-3-26-20(25)13(2)22-18(19(23)24)11-14-7-9-15(10-8-14)16-5-4-6-17(21)12-16/h4-10,12-13,18,22H,3,11H2,1-2H3,(H,23,24)/t13-,18-/s3
InChIKey
PWYAUIUPDMSWJH-CODVNQPLNA-N
SMILES
C(O)(=O)[C@@H](N[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC(Cl)=C2)C=C1 |&1:3,5,r|
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LHW090-A7 Usage And Synthesis

Description

LHW090-A7 is a compound developed as an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins. Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and, as such, are expected to induce natriuretic and diuretic effects.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

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