N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE Chemical Properties

Melting point:

172 °C

Boiling point:

427.4±34.0 °C(Predicted)

Density 

1.277±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

14.53±0.20(Predicted)

form 

powder

color 

Yellow

InChI

InChI=1S/C11H11NO2/c1-7(13)12-9-3-4-10-8(6-9)2-5-11(10)14/h3-4,6H,2,5H2,1H3,(H,12,13)

InChIKey

GHUPGGYDRVSZSW-UHFFFAOYSA-N

SMILES

C(NC1C=CC2=C(C=1)CCC2=O)(=O)C

Safety Information

Hazard Note 

Harmful

HS Code 

2924297099

N1-(1-OXO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE Usage And Synthesis

Definition

ChEBI: N1-(1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide is a member of indanones.

Synthesis

General procedure for the synthesis of 5-acetamido-1-indanone from N-(2,3-dihydro-1H-inden-5-yl)acetamide: To a stirred solution of N-(2,3-dihydro-1H-inden-5-yl)acetamide (11.5 g, 65.7 mmol) in acetic acid: ethyl acetate (1:1, 200 ml) was slowly added dropwise to a solution of chromium trioxide (15 g) dissolved in water at 0 °C 151.11 mmol) dissolved in water. The reaction mixture was continued to be stirred at room temperature for 3 hours. After completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with methanol/dichloromethane as eluent to afford the target product 5-acetamido-1-indanone (9 g, 85% yield) as a yellow solid. m/z = 190 [M + H]+ by LC-MS.

References

[1] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 548
[2] Journal of Chemical Research, 2013, vol. 37, # 4, p. 232 - 235
[3] Journal of Organic Chemistry, 1962, vol. 27, p. 70 - 76
[4] Physical Chemistry Chemical Physics, 2001, vol. 3, # 17, p. 3555 - 3561
[5] Patent: WO2013/62892, 2013, A1. Location in patent: Page/Page column 45

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