GNE-7915 (tosylate) Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: ≥ 50 mg/mL (81.22 mM); Water: < 0.1 mg/mL (insoluble)

form 

Solid

color 

White to off-white

GNE-7915 (tosylate) Usage And Synthesis

Uses

GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.

References

[1] Kavanagh ME, et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett.?2013 Jul 1;23(13):3690-6. DOI:10.1016/j.bmcl.2013.04.086
[2] Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33. DOI:10.1021/jm301020q