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NIBR189

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NIBR189 Basic information

Product Name:
NIBR189
Synonyms:
  • NIBR189
  • (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one
  • (2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one
  • CS-1583
  • NIBR-189; NIBR 189
  • (2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one
  • 2-Propen-1-one, 3-(4-bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-, (2E)-
  • Inhibitor,mice,small molecule,NIBR 189,autoimmune diseases,autoimmune,EBI2/GPR183,NIBR189,U937,NIBR-189,G protein,inhibit,migration
CAS:
1599432-08-2
MF:
C21H21BrN2O3
MW:
429.31
Product Categories:
  • api
Mol File:
1599432-08-2.mol
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NIBR189 Chemical Properties

Boiling point:
639.7±55.0 °C(Predicted)
Density 
1.403±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
-0.86±0.70(Predicted)
color 
White to off-white
InChI
1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+
InChIKey
OFHXXBRBGWUOHR-NYYWCZLTSA-N
SMILES
Brc1ccc(cc1)\C=C\C(=O)N2CCN(CC2)C(=O)c3ccc(cc3)OC
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Safety Information

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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NIBR189 Usage And Synthesis

Uses

(2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one recently known as NIBR 189, is a selective Epstein-barr virus-induced gene 2 (EBI-2) receptor antagonist, resulting in a modulation of immune responses related to auto-immune diseases.

Biological Activity

nibr189 is a small molecule antagonist of the epstein-barr virus-induced gene 2 (ebi2; gpr183) receptor with ic50 of 16 nm(binding) and 11 nm (functional).

in vivo

1.19Pharmacokinetic Properties of NIBR189 in Mice[1].
Mice
IV 1 mg/kg		Mice
PO 3 mg/kg
CL (μL/min/mg)16
t1/2 (h)1.1
Vss (L/kg)1.4
AUC (nmol·h/L)24353608
Cmax (nmol/L)835
tmax (h)1
F (%)49

storage

Store at +4°C

NIBR189Supplier

Shanghai Boyle Chemical Co., Ltd.
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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LETOPHARM LIMITED
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+86-21-5821 5861
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
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021-61350663 13052117465
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