Basic information Safety Supplier Related

Mutant IDH1-IN-1

Basic information Safety Supplier Related

Mutant IDH1-IN-1 Basic information

Product Name:
Mutant IDH1-IN-1
Synonyms:
  • Mutant IDH1-IN-1
  • IDH1-IN-1
  • N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-1H-benzimidazole-1-acetamide
  • CS-1779
  • Mutant IDH1 inhibitor 1
  • 1H-Benzimidazole-1-acetamide, N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-
  • Mutant IDH1IN1,Isocitrate Dehydrogenase (IDH),Inhibitor,inhibit,Mutant IDH-1-IN-1,Mutant IDH1 IN 1
  • 2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclohexyl-2-(o-tolyl)acetamide
CAS:
1355326-21-4
MF:
C30H31FN4O2
MW:
498.59
Product Categories:
  • Inhibitors
Mol File:
1355326-21-4.mol
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Mutant IDH1-IN-1 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
color 
White to off-white
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Mutant IDH1-IN-1 Usage And Synthesis

Uses

Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

IC 50

IDH1

References

[1] Deng G, et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. J Biol Chem. 2015 Jan 9;290(2):762-74. DOI:10.1074/jbc.M114.608497

Mutant IDH1-IN-1Supplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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info@chemexpress.com
Zhengzhou HSH Science & Technology Co., Ltd.
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0371-55932928 18937192232
Email
1282296214@qq.com
LETOPHARM LIMITED
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+86-21-5821 5861
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sales@letopharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266