ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > AF38469
AF38469
AF38469 Basic information
- Product Name:
- AF38469
- Synonyms:
-
- AF38469
- AF38469 (AF-38469)
- CS-2561
- Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-
- 2-((6-Methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid
- inhibit,AF 38469,Neurotensin Receptor,Inhibitor,AF38469
- 2-[(6-Methyl-2-pyridyl)carbamoyl]-5-(trifluoromethyl)benzoic Acid
- AF38469, 10 mM in DMSO
- CAS:
- 1531634-31-7
- MF:
- C15H11F3N2O3
- MW:
- 324.25
- Mol File:
- 1531634-31-7.mol
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AF38469 Chemical Properties
- Boiling point:
- 392.3±42.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: Soluble; Ethanol: Soluble
- form
- A solid
- pka
- 2.83±0.36(Predicted)
- color
- Off-white to light yellow
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AF38469 Usage And Synthesis
Uses
AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
in vivo
AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat[1].
References
[1] Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. DOI:10.1016/j.bmcl.2013.11.046
AF38469Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Artis Chemistry (Shanghai) Co. Ltd.
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- 86-21-60936353
Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
- info@chemexpress.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
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- 18149758185 18149758185;
- sales-cpd@caerulumpharma.com
Quality Control Solutions Ltd.
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- 66853366 13670046396
- sales@chem-strong.com