2-AMINOETHYL HYDROGEN SULFATE Chemical Properties

Melting point:

277 °C (dec.)(lit.)

Boiling point:

296.49℃[at 101 325 Pa]

Density 

1.344 (estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5130 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Methanol (Slightly), Water (Soluble)

form 

Fine Crystalline Powder

pka

-4.33±0.18(Predicted)

color 

White to slightly beige

Water Solubility 

almost transparency

BRN 

1704079

LogP

-3.96 at 25℃

CAS DataBase Reference

926-39-6(CAS DataBase Reference)

EPA Substance Registry System

Ethanol, 2-amino-, hydrogen sulfate (ester) (926-39-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

KJ6371000

HS Code 

29221990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

2-AMINOETHYL HYDROGEN SULFATE Usage And Synthesis

Chemical Properties

WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER

Uses

2-Aminoethyl Sulfate, is a building block used for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic compounds. It can be used in the preparation of Taurine (T007850).

Synthesis

General procedure for the synthesis of 2-aminoethyl sodium bisulfate from 2-aminoethanol: In a 100 mL three-necked flask equipped with a constant-pressure dropping funnel, a thermometer, and a magnetic stirrer, 9 mL (0.15 mol) of 2-aminoethanol and 9 mL of water were added. The reaction mixture was cooled to -5 to 5 °C using a cryogenic cooling circulation pump. An aqueous solution of 16.3 mL of sulfuric acid was prepared by mixing concentrated sulfuric acid with water in an equal volume ratio and slowly added dropwise to the three-necked flask through a constant pressure dropping funnel. After the dropwise addition, the reaction mixture was continued to be stirred for 0.5 hours. Subsequently, a vacuum distillation apparatus was switched to gradually increase the temperature of the reaction system to room temperature and water was removed by distillation at 15 mbar (as indicated by the oil pump). The distillation residue was transferred to 60 mL of anhydrous ethanol, stirred thoroughly and filtered. The filter cake was washed with 3 x 15 mL of anhydrous ethanol and dried to give 19.2 g of white solid, i.e., sodium 2-aminoethyl hydrogen sulfate in 90.72% yield.

Purification Methods

Crystallise the sulfate ester from water or dissolve it in water and add EtOH. [Beilstein 4 III 1414.]

References

[1] Patent: CN107739349, 2018, A. Location in patent: Paragraph 0054
[2] Agricultural and Biological Chemistry, 1991, vol. 55, # 10, p. 2537 - 2546
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 1540
[4] Patent: US2264759, 1939,
[5] Chemische Berichte, 1918, vol. 51, p. 1662

2-AMINOETHYL HYDROGEN SULFATE(926-39-6)Related Product Information

• Sodium bisulfate monohydrate
• D-GLUCOSAMINE-2,3-DISULFATE, DISODIUM SALT
• D-GLUCOSAMINE-3,4,6-TRISULFATE, DISODIUM SALT
• Sulfuric acid
• 2-AMINOETHYL HYDROGEN SULFATE
• H-SER(SO3H)-OH
• gonyautoxin I
• D-GLUCOSAMINE-3-SULFATE
• BOC-AIB-OSU
• gonyautoxin II
• gonyautoxin VIII
• H-D-SER(SO3H)-OH
• D-GLUCOSAMINE-2,3,6-TRISULFATE, TRISODIUM SALT
• GLCNAC-3S, NA
• pyridofylline
• GLCNAC-3S,6S,2NA
• D-GLUCOSAMINE-3,6-DI-O-SULPHATE (2NA)
• 4-(4-NITROBENZYL)-1-[2-(SULFONATOOXY)ETHYL]PYRIDINIUM