2-Chloropropionitrile Chemical Properties

Melting point:

54-55 °C

Boiling point:

120-122 °C (lit.)

Density 

1.012 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.413(lit.)

Flash point:

92 °F

storage temp. 

Sealed in dry,Room Temperature

InChI

InChI=1S/C3H4ClN/c1-3(4)2-5/h3H,1H3

InChIKey

JNAYPRPPXRWGQO-UHFFFAOYSA-N

SMILES

C(#N)C(Cl)C

NIST Chemistry Reference

CH3CHClCN(1617-17-0)

Safety Information

Hazard Codes 

T

Risk Statements 

10-23/24/25-36/37/38

Safety Statements 

16-26-27-36/37/39-45

RIDADR 

UN 3275 6.1/PG 2

WGK Germany 

3

HazardClass 

3.2

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

2-Chloropropionitrile Usage And Synthesis

Description

2-Chloropropionitrile (2-CPN) is a colorless flammable liquid with a characteristic acrid odor.

Uses

Major uses of this chemical are in pharmaceutics and polymer synthesis.

Uses

2-Chloropropionitrile was used as initiator during the single-pot atom-transfer radical polymerization under microwave irradiation for the synthesis of polyacrylonitrile. It was used in the synthesis of:

• nitrile functionalized methimazole-based ionic liquids
• (+)- and (-)-anatoxin

Environmental Fate

Most of the toxicity of propionitrile results from release of cyanide. Cause of death is due to lack of oxygen to the body’s cells, especially to the brain and heart cells.

Acquired resistance

According to Henry’s law constant of 1.43×10^-5 atmm3 mol^-1, vapor pressure of 2.770mmHg and water solubility of 45 g ml^-1 at 25°C are expected to indicate that volatilization from moist soil and water surfaces is expected to be an important fate process and also it can be volatilized from dry soil surfaces and exist as a vapor in the atmosphere.
When heated to decomposition, it emits very toxic fumes of chlorine-containing compounds: nitrogen oxides, hydrogen cyanide, and hydrogen chloride.

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