YK-3-237
YK-3-237 Basic information
- Product Name:
- YK-3-237
- Synonyms:
-
- B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
- YK3237,inhibit,Sirtuin,p53,breast,cancer,triple-negative,mtp53,Mutant,TNBC,Inhibitor,deacetylation,YK 3 237
- Boronic acid, B-[2-methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-
- (E)-(2-Methoxy-5-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenyl)boronic acid
- YK-3-237, 10 mM in DMSO
- YK 3-237 ，E0394
- CAS:
- 1215281-19-8
- MF:
- C19H21BO7
- MW:
- 372.18
- Mol File:
- 1215281-19-8.mol
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YK-3-237 Chemical Properties
- Boiling point:
- 616.2±65.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 8.08±0.58(Predicted)
- color
- White to light yellow
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YK-3-237 Usage And Synthesis
Uses
YK 3-237, is a sirtuin-1 (SIRT1) activator, and inhibits proliferation of breast cancer cell lines inducing G2/M cell cycle arrest and apoptosis.
Biological Activity
YK-3-237 is an activator of sirtuin-1 (SIRT1). YK-3-237 showed anti-proliferative activity toward triple-negative breast cancer, inducing G2/M cell cycle arrest and apoptosis. In a study on renal fibrosis, YK-3-237 caused enhanced expression of α-SMA and fibronectin, suggesting th at long-term use of SIRT1 activators may increase the risk or progression of chronic kidney disease.
IC 50
SIRT1
YK-3-237Supplier
Pharmacodia (Beijing) Co.,Ltd
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- +86-400-851-9921
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Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Tianjin Kailiqi Biotechnology Co., Ltd.
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- 15076683720
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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