ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > PD-126055 free acid
PD-126055 free acid
PD-126055 free acid Basic information
- Product Name:
- PD-126055 free acid
- Synonyms:
-
- PD-126055 free acid
- EMA401
- (3S)-2-(2,2-Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid
- Olodanrigan(EMA401)
- CS-2652
- Olodanrigan
- (S)-5-(benzyloxy)-2-(2,2-diphenylacetyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- OLODANRIGAN;EMA 401;EMA-401;EMA401
- CAS:
- 1316755-16-4
- MF:
- C32H29NO5
- MW:
- 507.58
- Product Categories:
-
- API
- Mol File:
- 1316755-16-4.mol
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PD-126055 free acid Chemical Properties
- Boiling point:
- 745.3±60.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);39.4(Max Conc. mM)
- form
- A crystalline solid
- pka
- 3.54±0.20(Predicted)
- color
- White to off-white
- InChIKey
- GHBCIXGRCZIPNQ-MHZLTWQESA-N
- SMILES
- C1C2=C(C(OCC3=CC=CC=C3)=C(OC)C=C2)C[C@@H](C(O)=O)N1C(C(C1=CC=CC=C1)C1=CC=CC=C1)=O
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PD-126055 free acid Usage And Synthesis
Uses
Olodanrigan is an intermediate used in the prepation of enantiopure angiotensin II type 2 receptor [AT2R] antagonist EMA401.
in vivo
EMA401 (10?mg/kg; p.o.) results in a significant attenuation of theta power and increase in paw withdrawal latencies (PWL) in rats at day 14 after chronic constriction injury (CCI)[4].
IC 50
AT2 Receptor
PD-126055 free acidSupplier
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