ACETAZOLAMIDE SODIUM
ACETAZOLAMIDE SODIUM Basic information
- Product Name:
- ACETAZOLAMIDE SODIUM
- Synonyms:
-
- ACETAZOLAMIDE SODIUM
- acetazolamidesodiumsalt
- diamoxsodium
- n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt
- n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt
- SODIUMACETAZOLAMIDE
- CAS:
- 1424-27-7
- MF:
- C4H7N4NaO3S2
- MW:
- 246.23
- Mol File:
- 1424-27-7.mol
ACETAZOLAMIDE SODIUM Chemical Properties
- storage temp.
- 4°C, away from moisture
- solubility
- DMSO : 100 mg/mL (407.76 mM; Need ultrasonic)
- form
- Solid
- color
- Powder fine white
ACETAZOLAMIDE SODIUM Usage And Synthesis
Uses
Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].
Definition
ChEBI: Acetazolamide sodium is an organic sodium salt. It contains an acetazolamide and an acetazolamide(1-).
brand name
Diamox (Duramed).
Safety Profile
ACETAZOLAMIDE SODIUM SALT ?? SODIUMACETAZOLAMIDE
in vivo
Acetazolamide (40 mg/kg) significantly potentiates the inhibitory effect of MS-275 on tumorigenesis in neuroblastoma (NB) SH-SY5Y xenografts[3].
?
Acetazolamide (40 mg/kg) and/or MS-275 treatment reduce expression of HIF1-α and CAIX in NB SH-SY5Y xenograft[3].
?
Acetazolamide (40 mg/kg), MS-275 and Acetazolamide+MS-275 reduce expression of mitotic and proliferative markers in NB SH-SY5Y xenografts[3].?
Acetazolamide (50 mg/kg; PO, for 3 days) significantly reduces the gonococcal load in the vagina of infected mice by 90%[6].
IC 50
CA Ⅸ
References
[1] Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156. DOI:10.1186/s12885-017-3126-7
[2] Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. DOI:10.1016/j.ejmech.2017.03.023
[3] Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306. DOI:10.3892/ol.2018.8529
[4] Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. DOI:10.1097/CRD.0b013e31822b4939
[5] Jabeen E, et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. DOI:10.1016/j.jphotobiol.2013.06.002
[6] Abutaleb NS, et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. DOI:10.1016/j.micpath.2022.105454
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