Gemcitabine monophosphate
Gemcitabine monophosphate Basic information
- Product Name:
- Gemcitabine monophosphate
- Synonyms:
-
- Gemcitabine monophosphate disodium salt
- Gemcitabine monophosphate disodium
- GEMCITABINE MONOPHOSPHATE DISODIUM SALT MONOHYDRATE; GEMCITABINE MONOPHOSPHATE DISODIUM; GEMMP
- GemMP
- Gemcitabine monophosphate disodium monohydrate
- 4-amino-1-((2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one, phosphate salt
- CAS:
- 1638288-31-9
- MF:
- C9H13F2N3NaO7P
- MW:
- 367.18
- Mol File:
- 1638288-31-9.mol
Gemcitabine monophosphate Chemical Properties
- storage temp.
- Store at 0-8 °C
- solubility
- DMSO:10.0(Max Conc. mg/mL);24.68(Max Conc. mM)
Gemcitabine monophosphate Usage And Synthesis
Uses
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles[1][2].
in vivo
Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1].
| Animal Model: | Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1] |
| Dosage: | 19.5 mg/kg, every other day, four injections |
| Administration: | Intravenous injection (i.v.) |
| Result: | Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis. |
References
[1] Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. DOI:10.1038/mt.2013.120
[2] Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. DOI:10.1002/adfm.201401076
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