(-)BI97D6 Chemical Properties

Boiling point:

892.2±65.0 °C(Predicted)

Density 

1.454±0.06 g/cm3(Predicted)

pka

6.23±0.20(Predicted)

(-)BI97D6 Usage And Synthesis

Uses

(-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values ??of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells[1].

IC 50

Bcl-xL: 0.076 μM (IC₅₀); Mcl-1: 0.025 μM (IC₅₀); Bcl-2: 0.031 μM (IC₅₀); Bcl-1: 0.122 μM (IC₅₀)

References

[1] Rongqing Pan, et al. "Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–) BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia." Blood, The Journal of the American Society of Hematology 126.3 (2015): 363-372. DOI:10.1182/blood-2014-10-604975