Liafensine Chemical Properties

Boiling point:

617.1±55.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

pka

7.42±0.40(Predicted)

Liafensine Usage And Synthesis

Uses

Liafensine (BMS-820836) is a triple monoamine reuptake inhibitor (TRI), that inhibits dopamine transporter, serotonin transporter and norepinephrine transporter, with IC50s of 5.67, 1.08 and 7.99 nM, respectively. Liafensine exhibits antidepressant activity[1].

Definition

ChEBI: Liafensine is a member of isoquinolines.

References

[1] Risinger R, et al., Evaluation of safety and tolerability, pharmacokinetics, and pharmacodynamics of BMS-820836 in healthy subjects: a placebo-controlled, ascending single-dose study. Psychopharmacology (Berl). 2014 Jun;231(11):2299-310. DOI:10.1007/s00213-013-3391-3