Basic information Safety Supplier Related

VAL-CIT-PAB-MMAD

Basic information Safety Supplier Related

VAL-CIT-PAB-MMAD Basic information

Product Name:
VAL-CIT-PAB-MMAD
Synonyms:
  • VAL-CIT-PAB-MMAD
  • Vat-Cit-PAB-MMAD
  • Vat-Cit-PAB-Monomethyl Dolastatin 10
  • Vat-Cit-PABMonomethyl
  • L-Valinamide, N-methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
  • 4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-3-methoxy-1-((R)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate
CAS:
1415329-13-3
MF:
C60H93N11O11S
MW:
1176.51
Mol File:
1415329-13-3.mol
More
Less

VAL-CIT-PAB-MMAD Chemical Properties

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
More
Less

VAL-CIT-PAB-MMAD Usage And Synthesis

Uses

Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.

IC 50

Auristatin

References

[1] Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9. DOI:10.1038/nchem.2415

VAL-CIT-PAB-MMADSupplier

Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-+86-530-529 6766,+86-15666160102 15666160102
Email
info@chuangli-chem.com
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Hangzhou Huarong Pharm Co., Ltd.
Tel
571-86758373 +8613588754946
Email
sales@huarongpharm.com