TLR7-IN-1
TLR7-IN-1 Basic information
- Product Name:
- TLR7-IN-1
- Synonyms:
-
- TLR7-IN-1
- TLR7-agonist-1
- CS-2748
- TLR7 agonist 2
- 5H-Pyrrolo[3,2-d]pyrimidin-2-amine, 4-[(5-methyl-3-isoxazolyl)methoxy]-5-(2-pyridinylmethyl)-
- inhibit,TLR7 agonist 2,TLR-7 agonist 2,Inhibitor,Toll-like Receptor (TLR)
- 4-[(5-methyl-1,2-oxazol-3-yl)methoxy]-5-[(pyridin-2-yl)methyl]-5H-pyrrolo[3,2-d]pyrimidin-2-amine
- TLR7 agonist 2, 10 mM in DMSO
- CAS:
- 1642857-69-9
- MF:
- C17H16N6O2
- MW:
- 336.35
- Mol File:
- 1642857-69-9.mol
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TLR7-IN-1 Chemical Properties
- Melting point:
- 147 - 149°C
- Boiling point:
- 655.1±65.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.89±0.30(Predicted)
- form
- Solid
- color
- White to Off-White
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TLR7-IN-1 Usage And Synthesis
Uses
TLR7-agonist-1, is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.
in vivo
TLR7 agonist 2 is found to be rapidly cleared in conjunction with our target profile. Both Cmax and AUC increase less than dose proportionally between 0.3 and 3 mg/kg and more than dose-proportionally between 3 and 10 mg/kg. TLR7 agonist 2 can induce an antiviral interferon stimulated gene (ISG) response without inducing an IFNα response at a low dose. TLR7 agonist 2 also induces a 2.7 log decrease in serum HBV viral load from 0.3 mg/kg, and a maximum 3.1 log decrease is observed for doses between 1 and 5 mg/kg[1].
TLR7-IN-1Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Beijing Solarbio Science & Tecnology Co., Ltd.
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- 010-50973130 18101056239
- 3193328036@qq.com
Twochem Co.Ltd.
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- 021-58111628 15800915896
- sales@twochem.com