tert-butyl hex-5-ynoate
tert-butyl hex-5-ynoate Basic information
- Product Name:
- tert-butyl hex-5-ynoate
- Synonyms:
-
- tert-butyl hex-5-ynoate
- hex-5-ynoic acid tert-butyl ester
- 5-Hexynoic acid tert-butyl ester
- 5-Hexynoic acid, 1,1-dimethylethyl ester
- tert-Butyl 5-Hexynoate
- Tert-butyl hex-5-ynoate - [B70772]
- CAS:
- 73448-14-3
- MF:
- C10H16O2
- MW:
- 168.23
- Mol File:
- 73448-14-3.mol
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tert-butyl hex-5-ynoate Chemical Properties
- Boiling point:
- 209.7±23.0 °C(Predicted)
- Density
- 0.929±0.06 g/cm3(Predicted)
- form
- Liquid
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tert-butyl hex-5-ynoate Usage And Synthesis
Uses
tert-Butyl hex-5-ynoate is the linker that can be used for PROTAC synthesis of PROTAC cGAS degrader-1 (HY-172208)[1].
References
[1] He P, et al., Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis. J Med Chem. 2025 Mar 13;68(5):5551-5572. DOI:10.1021/acs.jmedchem.4c02774
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