1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Chemical Properties

Density 

1.272±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 220 mg/mL (771.01 mM; Need ultrasonic)

pka

13.03±0.50(Predicted)

form 

Solid

color 

White to light yellow

1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Usage And Synthesis

Uses

(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68[1].

IC 50

JAK3: 144.8 nM (IC₅₀)

References

[1] Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyr-rolo[2,3-d]pyridinyl acrylamides. US20150158864A1.