ANTI-ANNEXIN I
ANTI-ANNEXIN I Basic information
- Product Name:
- ANTI-ANNEXIN I
- Synonyms:
-
- ANTI-LIPOCORTIN-1
- ANTI-LIPOCORTIN I
- Monoclonal Anti-p35 (Cdk5 Regulator) antibody produced in mouse
- Anti-MGC16386
- Anti-Cell division cycle associated 5
- Anti-MGC16386, SORORIN
- Anti-GRIF
- Anti-AMH antibody produced in rabbit
- MW:
- 0
- Product Categories:
-
- Alphabetical Index
- Antibodies for Cell Cycle
- Antibodies to Cell Cycle RegulatorsCell Biology
- Antibodies to Nuclear ProteinsAntibodies
- Cell Biology
- P1 to PN
- Mol File:
- Mol File
ANTI-ANNEXIN I Chemical Properties
- storage temp.
- −20°C
- form
- buffered aqueous solution
MSDS
- Language:English Provider:SigmaAldrich
ANTI-ANNEXIN I Usage And Synthesis
General Description
Annexin A1, ANXA1, also known as lipocortin I, is an anti-inflammatory protein originally identified as a phospholipase A2 (PLA2)-inhibitory protein. Its expression is induced by glucocorticoids in immune cells where it has been shown to promote cellular apoptosis. ANXA1 is a 40 kDa protein that binds to the cytosolic side of the cellular membrane in a Ca-dependent manner.
Biochem/physiol Actions
ANXA1 encodes a protein that belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.