H-TYR-GLY-PHE-GLY-GLY-OH Chemical Properties

Boiling point:

1028.0±65.0 °C(Predicted)

Density 

1.352±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

3.32±0.10(Predicted)

form 

Solid

color 

White to off-white

H-TYR-GLY-PHE-GLY-GLY-OH Usage And Synthesis

Uses

Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].

in vivo

References

[1] Chen YC, et al. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14). J Med Chem. 2002;45(8):1624-1632. DOI:10.1021/jm010479l
[2] Chen Z, et al. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)]. Protein Pept Lett. 2009;16(9):1074-1080. DOI:10.2174/092986609789055395
[3] Fazzi R, et al. Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice. Leuk Res. 2002;26(1) DOI:10.1016/s0145-2126(01)00091-1
[4] Battolla B, et al. The small peptide OGP(10-14) reduces proliferation and induces differentiation of TPO-primed M07-e cells through RhoA/TGFbeta1/SFK pathway. Med Sci Monit. 2011;17(1):SC1-SC5. DOI:10.12659/msm.881309

H-TYR-GLY-PHE-GLY-GLY-OH(105250-85-9)Related Product Information

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• H-TYR-GLY-PHE-GLY-GLY-OH
• ATGPLSPGPFGRR
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• PHYTOSULFOKINE-ALPHA
• H-ARG-PRO-GLY-GLY-GLY-ASP-MET-ARG-ASP-ASN-TRP-ARG-SER-GLU-LEU-TYR-LYS-TYR-LYS-VAL-OH
• CDR-H3/C2