(D-PHE11,HIS12)-SAUVAGINE, FRAGMENT 11-40 TRIFLUOROACETATE SALT Chemical Properties

storage temp. 

-20°C

solubility 

Water: soluble

form 

powder

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

(D-PHE11,HIS12)-SAUVAGINE, FRAGMENT 11-40 TRIFLUOROACETATE SALT Usage And Synthesis

Uses

Antisauvagine-30 Trifluoroacetate Salt is a CRF1 and CRF2 antagonist blocking secretions of cortisol and adrenocorticotropic hormone (ACTH). Used in studies involving stress and memory.

Biochem/physiol Actions

High-affinity antagonist for Corticotropin-releasing factor (CRF) receptor type 2 (CRF(2)).

References

[1] F M DAUTZENBERG. Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: evidence for evolutionary differences.[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 296 1: 113-120.
[2] A RÜHMANN. Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2beta-selective antisauvagine-30.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 26: 15264-15269. DOI: 10.1073/pnas.95.26.15264
[3] F. SANANBENESI. Mitogen-Activated Protein Kinase Signaling in the Hippocampus and Its Modulation by Corticotropin-Releasing Factor Receptor 2: A Possible Link between Stress and Fear Memory[J]. The Journal of Neuroscience, 2003, 16 1: 11436-11443. DOI: 10.1523/jneurosci.23-36-11436.2003
[4] MARCELA CRISTINA GARNICA-SIQUEIRA . Corticotrophin-releasing factor mediates vasoactive intestinal peptide-induced hypophagia and changes in plasma parameters[J]. Hormones and Behavior, 2018, 105: Pages 138-145. DOI: 10.1016/j.yhbeh.2018.08.008

(D-PHE11,HIS12)-SAUVAGINE, FRAGMENT 11-40 TRIFLUOROACETATE SALT()Related Product Information

• ANTISAUVAGINE-30
• SAUVAGINE