4-(Trifluoromethyl)cyclohexanone Chemical Properties

Boiling point:

82 °C

Density 

1.221 at 25 °C

refractive index 

n20/D1.400

Flash point:

76℃

storage temp. 

Inert atmosphere,Room Temperature

form 

liquid

color 

Clear, colourless

InChI

InChI=1S/C7H9F3O/c8-7(9,10)5-1-3-6(11)4-2-5/h5H,1-4H2

InChIKey

IPQDZFUZVJKAKZ-UHFFFAOYSA-N

SMILES

C1(=O)CCC(C(F)(F)F)CC1

Safety Information

Hazard Codes 

Xi,N,T

Risk Statements 

10-20/21/22-50-25

Safety Statements 

16-23-24/25-36/37/39-61-45

RIDADR 

1993

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

HS Code 

2914290090

4-(Trifluoromethyl)cyclohexanone Usage And Synthesis

Uses

4-(Trifluoromethyl)cyclohexanone (cas# 75091-99-5) is a compound useful in organic synthesis.

Synthesis

To a solution of 4-Trifluoromethylcyclohexanol (4.5 g, 26.7 mmol) in DCM (100 ml) was added Dess-Martin periodinane (13.6 g, 32 mmol) and stirred at rt for 2 h. After the reaction finished, the reaction mixture was concentrated in vacuo, sodium thiosulfate aqueous solution and diethyl ether were added and stirred for 30 min, and extracted with diethyl ether. The organic layer was dried over MgSO 4 , concentrated in vacuo at rt to give 4-(Trifluoromethyl)cyclohexanone (4.2 g, 94.6 %).

4-(Trifluoromethyl)cyclohexanone(75091-99-5)Related Product Information

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