Basic information Safety Supplier Related

2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE

Basic information Safety Supplier Related

2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE Basic information

Product Name:
2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE
Synonyms:
  • 2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE
  • 2-PMDQ
  • 3-MPPI
  • Imidazo[1,2-c]quinazolin-5(3H)-one, 2,6-dihydro-2-[(4-phenyl-1-piperazinyl)methyl]-
  • 2 PMDQ,2PMDQ
CAS:
139047-55-5
MF:
C21H23N5O
MW:
361.44
Mol File:
Mol File
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2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE Chemical Properties

Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble to 10 mM in DMSO and in ethanol
form 
Powder
pka
13.74±0.40(Predicted)
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2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE Usage And Synthesis

Uses

2-PMDQ is an analog of Ketanserin with beneficial hemodynamic effects in portal hypertensive rats. Anti-hypertensive effects.

Definition

ChEBI: 2-[(4-phenyl-1-piperazinyl)methyl]-3,6-dihydro-2H-imidazo[1,2-c]quinazolin-5-one is a member of piperazines.

Biological Activity

Very potent ligand for α 1 sites (K i for displacement of prazosin = 0.2 nM). Also binds to 5-HT 1A sites (K i = 50 nM).

2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONESupplier

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