CX-1632
CX-1632 Basic information
- Product Name:
- CX-1632
- Synonyms:
-
- CX-1632
- Tulrampator 1038984-31-4
- Tulrampator (Synonyms: CX-1632)
- Tulrampator (CX-1632)
- S 47445
- S47445
- S-47445
- TULRAMPATOR; S-47445; S 47445; S47445; CX-1632; CX 1632; CX1632;
- CAS:
- 1038984-31-4
- MF:
- C20H17FN4O3
- MW:
- 380.37
- Mol File:
- 1038984-31-4.mol
CX-1632 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:21.67(Max Conc. mg/mL);56.97(Max Conc. mM)
- form
- Solid
- color
- Light yellow to yellow
CX-1632 Usage And Synthesis
Uses
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder[1][2][3].
in vivo
Tulrampator (0.3-10 mg/kg, Oral gavage, once a day for 4-5 weeks) has anxiolytic-like and antidepressant-like effects in the CORT Mice Model[2].
Tulrampator (1-10 mg/kg, Intraperitoneal injection, once a day for 4 weeks) reverts olfactory bulbectomy (OB)-induced hyperactivity and anxiety in bilateral olfactory bulbectomy mice model[3].
| Animal Model: | chronic corticosterone administration (CORT) mice[2] |
| Dosage: | 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg |
| Administration: | Oral gavage (p.o.) |
| Result: | Reversed anxio-depressive phenotype in a neurogenesis-dependent task. Decreased the corticosterone-induced increase in emotionality. Had a rapid onset of effect on anhedonia in the rat Chronic Mild Stress (CMS) model. Stimulated cell proliferation, survival and neuronal maturation in the dentate gyrusof the hippocampus. |
| Animal Model: | bilateral olfactory bulbectomy mice model[3] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Significantly reverted OB-induced hyperactivity after 28 days. Increased open field central activity in OB mice. |
References
[1] Bretin S, et al. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors [J]. PLoS One, 2017, 12(9): e0184429.
[2] Mendez-David I, et al. S 47445 produces antidepressant-and anxiolytic-like effects through neurogenesis dependent and independent mechanisms [J]. Frontiers in pharmacology, 2017, 8: 462.
[3] Pilar-Cuellar F, et al. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice [J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, 93: 205-213.
[4] Wilkinson ST, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2018 Nov 14. pii: S1359-6446(18)30376-3. DOI:10.1016/j.drudis.2018.11.007
CX-1632Supplier
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