4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Chemical Properties

Melting point:

213 °C(Solv: ethanol (64-17-5))

Boiling point:

396.3±17.0 °C(Predicted)

Density 

1.333±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Solid

pka

3.33±0.10(Predicted)

color 

Pale brown

Safety Information

Hazard Codes 

Xi

HS Code 

2933399990

4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Usage And Synthesis

Uses

It is used as a pharmaceutical intermediate.

Synthesis

Step 2: Synthesis of 4-(pyridin-3-yl)thiazol-2-amine: 2-bromo-1-(pyridin-3-yl)ethanone (2 g, 1 eq.) was dissolved in ethanol (18.46 mL) followed by addition of thiourea (0.543 g, 0.7 eq.). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was cooled to 4 °C. During this process, the product precipitated as dihydrobromide. The precipitate was collected by filtration and dried. The resulting 4-(pyridin-3-yl)thiazol-2-amine dihydrobromide was dissolved in warm water (11 mL) and stirred for 5 minutes. Subsequently, aqueous ammonium hydroxide solution (17 mL) was added to this solution and stirring was continued. At this point, the target product slowly precipitated as a yellow solid. The solid product was separated by filtration and dried under vacuum conditions to give 2 g of 4-(pyridin-3-yl)thiazol-2-amine in 56% yield. The product was analyzed by LCMS showing m/z of 178.01 (M + H); 1H NMR (400 MHz, CD3OD) data were as follows: δ 8.96 (d, J=0.80 Hz, 1H), 8.44 (dd, J=1.60,4.80 Hz, 1H), 8.19-8.22 (m, 1H), 7.43-7.47 (m, 1H), and 7.05 (s, 1H).

References

[1] Patent: WO2014/74675, 2014, A1. Location in patent: Paragraph 00222
[2] Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 1137 - 1141
[3] Patent: WO2012/82817, 2012, A1. Location in patent: Page/Page column 93-94
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 2, p. 560 - 564

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