6-CHLOROMELATONIN
6-CHLOROMELATONIN Basic information
- Product Name:
- 6-CHLOROMELATONIN
- Synonyms:
-
- N-Acetyl-6-chloro-5-methoxytryptamine
- N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide
- n-(2-(6-chloro-5-methoxy-1h-indol-3-yl)ethyl)-acetamid
- N-[2-(6-CHLORO-5-METHOXYINDOL-3-YL)ETHYL]ACETAMIDE
- 6-CHLOROMELATONIN
- Melatonin 6-Chloro Impurity
- Acetamide, N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]-
- Melatonin Impurity 8
- CAS:
- 63762-74-3
- MF:
- C13H15ClN2O2
- MW:
- 266.72
- Mol File:
- 63762-74-3.mol
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6-CHLOROMELATONIN Chemical Properties
- Melting point:
- 147-148 °C
- Boiling point:
- 536.7±50.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- alcohol: soluble
- pka
- 15.99±0.30(Predicted)
- form
- Powder
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Safety Information
- Hazard Codes
- T
- Risk Statements
- 60-23/24/25-36/37/38
- Safety Statements
- 53-26-36/37/39-45
- WGK Germany
- 3
- RTECS
- AB5750000
MSDS
- Language:English Provider:SigmaAldrich
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6-CHLOROMELATONIN Usage And Synthesis
Uses
6-Chloromelatonin is a potent agonist of the melatonin receptors.
Definition
ChEBI: N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide is a member of acetamides.
Biological Activity
Potent melatonin agonist (pK i values are 9.10 and 9.77 for human recombinant MT 1 and MT 2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.
in vivo
Rats injected with the melatonin agonist, 6-chloromelatonin (0.5 mg/kg) on the day after the phase shift has markedly higher excretion rates of 6-sulphatoxymelatonin compared to those of the controls[5].
IC 50
MT1: 8.9 (pKi); MT2: 9.1 (pKi)
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