Biotin-Teg-Nh2 Tfa
Biotin-Teg-Nh2 Tfa Basic information
- Product Name:
- Biotin-Teg-Nh2 Tfa
- Synonyms:
-
- Biotin-Teg-Nh2 Tfa
- 1H-Thieno[3,4-d]imidazol-2(3H)-one, 4-[8-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]-5-oxooctyl]tetrahydro-, (3aS,4S,6aR)-, 2,2,2-trifluoroacetate (1:1)
- CAS_1334172-59-6
- Biotin-C1-PEG3-C3-amine TFA
- Biotin-dPEG??-NH?+TFA-
- Biotin-dPEG??-NH?+TFA- (QBD-10193)
- CAS:
- 1334172-59-6
- MF:
- C20H38N4O5S.C2HF3O2
- MW:
- 545.62
- Mol File:
- 1334172-59-6.mol
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Biotin-Teg-Nh2 Tfa Usage And Synthesis
Uses
Biotin-C1-PEG3-C3-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
Biotin-C1-PEG3-C3-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Biotin-Teg-Nh2 TfaSupplier
Borenpharm Co., Ltd
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