(+)-Oxanthromicin Chemical Properties

Boiling point:

896.2±65.0 °C(Predicted)

Density 

1.62±0.1 g/cm3(Predicted)

solubility 

DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble

form 

A solid

pka

1.97±0.40(Predicted)

(+)-Oxanthromicin Usage And Synthesis

Description

(+)-Oxanthromicin is an enantiomer of the rare Streptomyces metabolite (?)-oxanthromicin.¹ It inhibits K-Ras plasma membrane localization in MDCK cells with an IC₅₀ value of 62.5 μM.

References

1. Salim, A.A., Xiao, X., Cho, K.-J., et al. Rare Streptomyces sp. polyketides as modulators of K-Ras localisation Org. Biomol. Chem. 12(27),4872-4878(2014).