C18 Globotriaosylceramide (d18:1/18:0) Chemical Properties

Boiling point:

1132.1±65.0 °C(Predicted)

Density 

1.22±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Chloroform:Methanol (2:1): Soluble; DMSO: Soluble; Methanol: Warmed

form 

A solid

pka

12.76±0.70(Predicted)

C18 Globotriaosylceramide (d18:1/18:0) Usage And Synthesis

Description

C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. [Matreya, LLC. Catalog No. 1529]

Definition

ChEBI: Alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/18:0) is a glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/18:0). It has a role as a mouse metabolite. It is functionally related to an octadecanoic acid.