Basic information Safety Supplier Related

8-Bromo-3'-deoxy-3'-fluoroguanosine

Basic information Safety Supplier Related

8-Bromo-3'-deoxy-3'-fluoroguanosine Basic information

Product Name:
8-Bromo-3'-deoxy-3'-fluoroguanosine
Synonyms:
  • 8-Bromo-3'-deoxy-3'-fluoroguanosine
  • Guanosine, 8-?bromo-?3'-?deoxy-?3'-?fluoro- (9CI)
  • 8-Bromo-3’-deoxy-3’-fluoroguanosine
  • 2-amino-8-bromo-9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
CAS:
847649-50-7
MF:
C10H11BrFN5O4
MW:
364.13
Mol File:
847649-50-7.mol
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8-Bromo-3'-deoxy-3'-fluoroguanosine Chemical Properties

Boiling point:
728.1±70.0 °C(Predicted)
Density 
2.53±0.1 g/cm3(Predicted)
pka
12.34±0.70(Predicted)
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8-Bromo-3'-deoxy-3'-fluoroguanosine Usage And Synthesis

Uses

8-Bromo-3’-deoxy-3’-fluoroguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

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