TR antagonist 1
TR antagonist 1 Basic information
- Product Name:
- TR antagonist 1
- Synonyms:
-
- TR antagonist 1
- Benzenepropanoic acid, 3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-5-[(1E)-2-(4-pyridinyl)ethenyl]phenoxy]-
- CAS:
- 500794-88-7
- MF:
- C25H23Br2NO4
- MW:
- 561.26
- Mol File:
- 500794-88-7.mol
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TR antagonist 1 Chemical Properties
- Boiling point:
- 636.5±55.0 °C(Predicted)
- Density
- 1.553±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : ≥ 83.3 mg/mL (148.42 mM)
- pka
- 4.51±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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TR antagonist 1 Usage And Synthesis
Uses
TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
in vivo
TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model[1].
References
[1] Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7. DOI:10.1021/jm060521i
TR antagonist 1Supplier
Nanjing Norris-Pharm Technology Co., Ltd
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