MRT 68921 dihydrochloride Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in H2O:33.3(Max Conc. mg/mL);65.6(Max Conc. mM)

form 

Solid

color 

White to off-white

Water Solubility 

Soluble to 100 mM in water

MRT 68921 dihydrochloride Usage And Synthesis

Description

MRT68921 is an inhibitor of ULK1 and ULK2 (IC50s = 2.9 and 1.1 nM, respectively).

Uses

MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively[1].

target

MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.

storage

Desiccate at RT

References

[1] Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. DOI:10.1074/jbc.C114.627778