Eltoprazine Dihydrochloride
Eltoprazine Dihydrochloride Basic information
- Product Name:
- Eltoprazine Dihydrochloride
- Synonyms:
-
- Eltoprazine Dihydrochloride
- 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine Dihydrochloride
- Eltoprazine 2HCl
- Eltoprazine dihydrochloride, 10 mM in DMSO
- CAS:
- 143485-51-2
- MF:
- C12H17ClN2O2
- MW:
- 256.73
- Mol File:
- 143485-51-2.mol
Eltoprazine Dihydrochloride Chemical Properties
- Melting point:
- 257 °C(dec.)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
Eltoprazine Dihydrochloride Usage And Synthesis
Uses
Eltoprazine (DU 28853) dihydrochloride is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine dihydrochloride shows antiaggressive and anxiogenic effects[1][2].
in vivo
Rats are chronically treated with Mianserin (10 mg/kg i.p.) or Eltoprazine (1 mg/kg i.p.) and are tested in the elevated plus-maze test for anxiety. Mianserin and Eltoprazine display opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while Eltoprazine shows anxiogenic-like ones[2].
References
[1] Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177(1-2):55-66. DOI:10.1016/0014-2999(90)90549-l
[2] Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31. DOI:10.1016/0014-2999(94)90035-3
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