NSC49652 Chemical Properties

Boiling point:

414.3±45.0 °C(Predicted)

Density 

1.241±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 20.83 mg/mL (92.48 mM)

pka

7.68±0.30(Predicted)

form 

Solid

color 

Light yellow to yellow

InChI

1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+

InChIKey

CRWNZUBUBIULHB-BQYQJAHWSA-N

SMILES

OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O

Safety Information

WGK Germany 

WGK 3

HS Code 

2914310000

Storage Class

11 - Combustible Solids

NSC49652 Usage And Synthesis

Uses

(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propenone is used in the synthesis of 2,4,6-Trisubstituted Pyrimidines.

Biological Activity

NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) th at targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.