TRAF-3 ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

TRAFs are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses. Members of the TRAF family share a common carboxy-terminal "TRAF domain", which mediates interactions with associated proteins; many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified, TRAF1 and TRAF2, were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2. The six known TRAFs act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation, and stress responses.

References

[1] Arch, R.H. et al. (1998) Genes Dev 12, 2821-30.
[2] Chung, J.Y. et al. (2002) J Cell Sci 115, 679-88.
[3] Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-91.
[4] Rothe, M. et al. (1994) Cell 78, 681-92.

TRAF-3 ANTIBODY()Related Product Information

• TRAF1 (H-3)
• TRAF6 (D-10)
• TRAF3 (G-6) AC
• TRAF1 (45D3) Rabbit mAb
• TRAF4 (B-9)
• TRAF2 (H-10)
• TRAF3 (G-6)
• TRAF2 (F-2)
• TRAF6 (D21G3) Rabbit mAb
• TRAF1 (1F3) Rat mAb
• TRAIL (C92B9) Rabbit mAb
• TRAF2 (C192) Antibody