IACS-8968 Chemical Properties

Density 

1.55±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:50.0(Max Conc. mg/mL);131.11(Max Conc. mM)

form 

Solid

pka

9.95±0.40(Predicted)

color 

Light yellow to yellow

IACS-8968 Usage And Synthesis

Uses

IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

References

[1] ARYL SULFONOHYDRAZIDES. WO 2017189386 A1
[2] Hamilton MM, Mseeh F, McAfoos TJ, et al. Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme. J Med Chem. 2021;64(15):11302-11329. DOI:10.1021/acs.jmedchem.1c00679