1808113-09-8 Chemical Properties

Boiling point:

631.8±55.0 °C(Predicted)

Density 

1.287±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 100 mg/mL (233.36 mM);Water : < 0.1 mg/mL (insoluble)

form 

Solid

pka

13.32±0.70(Predicted)

color 

Light yellow to yellow

1808113-09-8 Usage And Synthesis

Uses

Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.

References

[1] Kalin JH, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 Jan 4;9(1):53. DOI:10.1038/s41467-017-02242-4