N/aa Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.88(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);14.65(Max Conc. mM)

form 

A crystalline solid

color 

White to off-white

N/aa Usage And Synthesis

Description

AUT1 is a positive modulator of the voltage-gated potassium channel subtypes K_v3.1b, K_v3.2a, and K_v3.3 (EC₅₀s = 4.7, 4.9, and 31.6 μM, respectively, in a patch-clamp assay). It is selective for K_v3.1b, K_v3.2a, and K_v3.3 over K_v1.5 and K_v7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT₃ receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 μM.

Uses

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione, is a novel modulator of Kv3 potassium channels which biological studies have shown it regulates the firing of parvalbumin-positive cortical interneurons.