2-Trisilanol, 1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)- Chemical Properties

Boiling point:

235.1±23.0 °C(Predicted)

Density 

0.833±0.06 g/cm3(Predicted)

refractive index 

n/D 1.496

storage temp. 

2-8°C, sealed storage, away from moisture

form 

liquid

pka

15.57±0.53(Predicted)

Appearance

Colorless to light yellow Liquid

2-Trisilanol, 1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)- Usage And Synthesis

Uses

Under a dual catalytic copper/photoredox manifold, this supersilanol has been demonstrated by the MacMillan lab to be an excellent reagent for the trifluoromethylation of alkyl halides and aryl halides to yield alkyl-CF₃ and aryl-CF₃ in high yields. In both cases, these reactions exhibit wide substrate scope with good functional group tolerance. More specifically, a variety of 5-membered and 6-membered heteroaryl halides can be readily converted to the corresponding trifluoromethylheteroarenes under mild conditions. To be use in conjunction with dMesSCF₃ (901466) and Ir photocatalyst (902217 or 902225).

reaction suitability

reaction type: C-C Bond Formation