3'-O-Me-G(iBu)-2'-phosphoramidite
3'-O-Me-G(iBu)-2'-phosphoramidite Basic information
- Product Name:
- 3'-O-Me-G(iBu)-2'-phosphoramidite
- Synonyms:
-
- 3'-O-Me-G(iBu)-2'-phosphoramidite
- Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-N-(2-methyl-1-oxopropyl)-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
- 5’-O-DMTr-N2-iso-butyroyl-3’-O-methyl guanosine-2’-CED-phosphoramidite
- 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-N-(2-methyl-1-oxopropyl)-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] Guanosine
- 3’-O-Me-G(iBu)-2’-phosphoramidite
- (2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2-isobutyramido-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- CAS:
- 179479-04-0
- MF:
- C45H56N7O9P
- MW:
- 869.94
- Mol File:
- 179479-04-0.mol
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3'-O-Me-G(iBu)-2'-phosphoramidite Usage And Synthesis
Uses
3’-O-Me-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
References
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100
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