3'-O-MOE-G(iBu)-2'-phosphoramidite Chemical Properties

pka

9.16±0.20(Predicted)

InChIKey

BWLKVJLYUDLOLH-KEFUZROQNA-N

SMILES

C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=NC3C(NC(NC(=O)C(C)C)=NC2=3)=O)[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H]1OCCOC |&1:25,27,44,59,r|

3'-O-MOE-G(iBu)-2'-phosphoramidite Usage And Synthesis

Description

3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)

Chemical Properties

White to off-white powder

Uses

3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

References

[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100