Amino-ethyl-SS-PEG3-NHBoc Chemical Properties

Boiling point:

506.8±50.0 °C(Predicted)

Density 

1.133±0.06 g/cm3(Predicted)

pka

12.23±0.46(Predicted)

Amino-ethyl-SS-PEG3-NHBoc Usage And Synthesis

Uses

Amino-ethyl-SS-PEG3-NHBoc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268